Interaction Checker

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Prescribing Resources

We have produced a series of materials in PDF format to aid prescribing.

Treatment Selectors show interactions between key antiretrovirals and drugs used to treat a range of common comorbidities.

Prescribing and Dosing Guidance give advice and recommendations for the use of HIV drugs in specific patient populations.

Interactions Explained describe the pharmacology of different mechanisms of interaction that may occur with HIV therapy.

Interaction Summary Tables provide an overview of interactions between HIV drugs and the comedications listed in the interaction checker.

Pharmacokinetic Fact Sheets contain information on the pharmacokinetics, metabolism and disposition of HIV drugs and have been collated from product labels and published literature on licensed doses (unless otherwise stated).

Please click on the headings below to see the full range of resources within each section.

Treatment Selectors (by therapeutic indication)

Analgesics

Updated December 2023

Anticoagulants & Antiplatelets

Updated December 2023

Antidepressants

Updated December 2023

Anti-Diabetics

Updated December 2023

Anti-Malarials

Updated December 2023

Antipsychotics

Updated December 2023

Anti-Tuberculosis Drugs

Updated December 2023

Anxiolytics & Hypnotics

Updated December 2023

Beta Blockers

Updated December 2023

Bronchodilators for COPD

Updated December 2023

Calcium Channel Blockers

Updated December 2023

Cancer Therapies

Updated December 2023

Contraceptives

Updated December 2023

Corticosteroids

Updated December 2023

Herbal and Mineral Supplements

Updated December 2023

Hormone Replacement Therapy (HRT)

Updated December 2023

Hypertensives

Updated December 2023

Immunosuppressants for SOT

Updated December 2023

Lipid Lowering

Updated December 2023

Pulmonary Anti-hypertensives

Updated December 2023

ARVs and Recreational Drugs

Updated December 2023

Prescribing and Dosing Guidance

Use of apixaban with strong CYP3A4 and P-gp inhibitors

Updated March 2024

ARV absorption and gastric surgery

Updated October 2023

ARVs for patients with swallowing difficulties

Updated December 2022

ARVs and food requirements

Updated October 2022

Dosing of ARVs for patients with renal impairment

Updated November 2022

Interactions with hormone therapy for gender affirmation

Updated October 2022

Interaction potential of chemsex drugs

Updated October 2022

Interactions with FTC/TDF PrEP and long-term use medications

Updated December 2022

Prescribing guidance for elderly PLWH

Updated October 2022

Guidance for the use of non-oral steroids and strong CYP3A4 inhibitors

Updated October 2022

Dosing of selected non-ARVs for patients with renal impairment

Updated October 2022

Considerations and interactions when switching from ritonavir-boosted to cobicistat-boosted atazanavir or darunavir

Updated October 2022

Interactions Explained

Enzyme induction by flucloxacillin

Updated April 2024

Dose dependent enzyme induction

Updated December 2022

Interactions following oral, intramuscular or subcutaneous administration

Updated October 2022

Interactions with herbal and mineral supplements

Updated October 2022

Interactions with integrase inhibitors and cations in antacids and supplements/vitamins

Updated October 2022

Interaction Summary Tables

Interactions with Protease Inhibitors

Updated December 2023

Interactions with NNRTIs

Updated December 2023

Interactions with NRTIs

Updated December 2023

Interactions with Integrase Inhibitors

Updated December 2023

Interactions with Entry, Attachment and Capsid Inhibitors

Updated December 2023

Interactions between key ARVs

Updated October 2023

Pharmacokinetic Fact Sheets

Abacavir (ABC)

Updated March 2016

Albuvirtide

Updated October 2022

Atazanavir

Updated March 2016

Bictegravir

Updated October 2018

Cabotegravir (IM)

Updated February 2021

Cabotegravir (oral)

Updated February 2021

Cobicistat

Updated March 2016

Dapivirine (vaginal ring)

Updated July 2021

Darunavir

Updated October 2018

Dolutegravir

Updated March 2016

Doravirine

Updated March 2023

Efavirenz

Updated March 2016

Elvitegravir

Updated March 2016

Emtricitabine (FTC)

Updated March 2016

Etravirine

Updated March 2016

Fostemsavir

Updated July 2021

Lamivudine (3TC)

Updated March 2016

Lenacapavir

Updated October 2022

Lopinavir

Updated March 2016

Maraviroc

Updated March 2016

Nevirapine

Updated March 2016

Raltegravir

Updated March 2016

Rilpivirine (IM)

Updated February 2021

Rilpivirine (oral)

Updated February 2021

Ritonavir

Updated March 2016

Tenofovir alafenamide (TAF)

Updated January 2024

Tenofovir-DF (TDF)

Updated March 2016

Zidovudine

Updated March 2016

Drug Interactions with 3HP for TB

Drug interaction summary tables and interaction notes for weekly isoniazid/rifapentine (3HP)

Updated October 2021
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