The last two months have seen the addition of three new comedications, along with the updating of several prescribing resources to include the new additions and revisions to existing interactions.
New comedications
Berberine (Herbals/Supplements/Vitamins)
Deutivacaftor/Tezacaftor/Vanzacaftor (Cystic Fibrosis Agents)
Vonoprazan (Gastrointestinal Agents)
Revised interaction classifications (colour changes)
The following interactions with encorafenib have been updated due to a new study showing encorafenib to be a strong inducer of CYP3A4:
↑ Green to Red - Doravirine, doravirine/lamivudine/tenofovir-DF, bictegravir/emtricitabine/tenofovir alafenamide, cabotegravir (oral), cabotegravir PrEP,
↑ Yellow to Red - Rilpivirine (alone and in combinations), fostemsavir
↑ Amber to Red - Lenacapavir (as ART and PrEP)
↑ Green to Amber - Dolutegravir (alone and non-rilpivirine combinations), maraviroc
Updated Prescribing Resources
Treatment Selector for Diabetes Therapies
Interaction Summary Tables for PIs, NNRTIs, NRTIs, Integrase Inhibitors, Entry, Attachment & Capsid Inhibitors, and ARVs for PrEP
